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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

“2017年上半年,我们将看到许多头条新闻报道(新兴市场出口增长)提速,”瑞银(UBS)新兴市场跨资产战略部门主管巴努?巴韦贾(Bhanu Baweja)表示。他认为,今年第一季度新兴市场出口(以美元计)将同比增长8%至13%,“完全摆脱”目前报道的负增长。
This is Us

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

试图推动亚洲ETF持续繁荣但迄今未获成功的公司表示,有必要从根本上改革似乎表明,市场将由说服监管机构和客户重塑行业格局的长期努力定义。
这些情况眼下一个都不存在。去年12月开始的美联储政策紧缩已经暂停。联邦基金利率(银行间隔夜拆借利率)估计低于自然利率逾一个百分点。美联储一直未作出意外之举。例如,美联储去年12月将政策利率提升25个基点之前发出了大量信号。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Baoneng is believed to have borrowed heavily to fund its share purchases in Vanke and is now the developer’s largest single shareholder with a 25 per cent stake.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

We should stipulate at this point that neither of us have any idea how good this draft is going to be because the college season is barely underway. It sure looks nice, what with all those freshmen stacked up together in the lottery.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

哈佛大学连续16年位居榜首,斯坦福大学和剑桥大学仍分别位列第二、第三名。
“Tangerine” (Sean Baker)
为保证更快的经济增长就必须要要消除美联储所担忧的另一个恶魔:通货紧缩,或者说价格下降。Baumohl 称“经济增长达到3%以上,并且自90年代以来新增了大量工作的国家发生通货紧缩几乎是不可能的”。
It was the second weekend in a row that Venezuela's socialist government opened the long-closed border with Colombia and by 6 a.m. Sunday a line of would-be shoppers snaked through the entire town of San Antonio del Tachira. Some had traveled in chartered buses from cities 10 hours away.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Yan Pu, head of portfolio review in Asia at Vanguard, suspects the Asian product mix may be holding things back. For example, Asian providers offer plenty of equity ETFs but very few fixed income products. In the US, she notes, fixed income ETFs are growing rapidly.
“Even though there is significant awareness [of the role of Fed policy], market dynamics can become unstable or unfavourable relatively easily,” he says. “Then you get into a self-reinforcing cycle of selling pressure.”
在经过了漫长的海选和五天紧张的半决赛之后,11位候选选手中其中一位成为了第八季英国达人秀2014年的冠军。
唐同学怀疑水中被混合了有毒物质,便把此事报告给班长和老师。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

《极盗车神》特别有趣,虽然它未必会使你一直捧腹大笑,但全片都很欢乐。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

激情、毅力和积极的心态,是创业成功的关键。培养这些特质要有天赋和一些小技巧。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

201202/172834.shtmlChinese entrepreneur Wang Xing stays in touch with a sister in California and an uncle in Australia through chat software that offers a glimpse of how China's Internet companies can compete globally.
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

新兴市场投资者不需要被提醒美联储(Fed)对新兴市场资产的重要性——不是吗?
不过,多个大城市新建住宅价格增速似乎已显著放缓。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Transforming and upgrading the real economy through innovation
吉尔伯特称,冬季假期会让这个领域的热度降低,但真正的试金石在于各家公司能否开发出可以通过“返回考验”的可穿戴设备——如果人们已经走出了家门好几步,依然决定返回去取忘带了的可穿戴设备,就像他们去取忘掉的钱包、钥匙、手机一样,这个设备就成功了。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

除了印度,其他金砖国家——巴西,俄罗斯,中国和南非——也削减了对美国政府债券的持有。
In the foreseeable future, China will see the boom of enterprises in tertiary industry. Related majors, including law, journalism and communication, and management, are expected to play a bigger role, according to the report.
Amazon founder Jeff Bezos rose to No. 3 on the list for the first time, thanks to the jump in in Amazon shares, which boosted his net worth to $72.8 billion.
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

节目37 相声《东西南北大拜年》,赵炎 逗笑 逗乐 大新等

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

每个员工都想偶尔得到上级的鼓励,优秀的老板们懂得认识和感激员工贡献的重要性。这并不意味着要对员工们作出一定的薪资奖励,而是合理的有意义的表达感激之情。
这些各不相同的胡子是设计师弗朗西丝·汉农(Frances Hannon)设计的,在安德森的多部电影中(比如《青春年少》[Rushmore]和《水中生活》[The Life Aquatic With Steve Zissou]),她都为比尔·默里(Bill Murray)设计了面部毛发。这次,她让该片的很多演员留起胡子,供她修剪成任何想要的形状。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

时间:2009-07-16 编辑:vicki

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
From the themed collection: 今年西安落户人口突破50万
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

contribution

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

尽管中国在设计制造能与波音737或空客A320媲美的大飞机上仍有很长的路要走,但发展趋势很显著。中国航空工业正走向一个崭新的发展阶段并不断迈向成熟。The first flight of the Comac C919. Credit: Comac
['gri:nhaus]
据此网站统计,排名第二的慈善明星是前迪斯尼明星后转型歌手的麦莉塞勒斯。准爸爸查宁塔图姆名列第三。
vt. 打碎,破掉

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: “以房养老”保险3年只卖了90份
Review Article

Influenza neuraminidase: A druggable target for natural products

3. You support the teams that I support.
南非总统雅各布?祖马的工资于三月份上调4%,但由于南非兰特的贬值,换算成美元后,其收入较去年实际有所下滑。
The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.
['?unip]
其中涉嫌售假的占比近45%,同比去年上升18.2%。消费者差评、频繁退货、投诉案例也很多。部分商家通过虚假低价的商业陷阱来促销商品。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
From the themed collection: 2015财年涂料巨头净利润大幅增长
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

However, in season two Friends took a big leap toward equality by featuring a gay wedding when Carol married her girlfriend Susan. Behind the scenes, executive producer Marta Kauffman said, "NBC expected thousands and thousands of phone calls and hate mail." However, after the episode aired, they received only four antagonistic letters. As it turns out, people just didn't care that much.
《副总统》(Veep):Netflix公司的热门剧《纸牌屋》(House of Cards)今年露出疲态,但另一部讽刺华盛顿的HBO电视剧《副总统》却在第三季中更上一层楼。塞琳娜(朱莉娅·路易斯-德莱弗斯[Julia Louis-Dreyfus]饰)和助手加里(Gary,托尼·黑尔[Tony Hale]饰)在洗手间里发现自己即将成为总统后,激动得失声大笑,成为2014年喜剧片中最滑稽的一幕。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
From the themed collection: 95后最爱重庆民宿
Critical Review

The role of biosensors in the detection of emerging infectious diseases

['sep?reit]

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 广东企业瞄准绿色建材市场蛋糕
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

然而,国家也很警惕网络金融的快速发展,该领域基本不受监管,发生系统性危机的风险可能会很高。据摩根士丹利(Morgan Stanley)和中国研究机构“网贷之家”的调查显示,自2007年以来,中国有370家P2P贷款平台倒闭,其中270家是在过去的一年中倒闭的。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

"The online Internet anti-corruption bid mostly relies on text, photos and videos and it is easy to be superficial if corrupt officials are only exposed this way."
We will step up the development of public facilities in rural areas.
排名第一的项目:清华-欧洲工商管理学院EMBA
中国中央和地方政府会对技术升级方面投入更多的经费。 包括现代化农业、运输、医疗等方面。这些积极的投资将会进一步提高中国生产和制造业的竞争能力。这将是一次国家行为,目的是为了推动提高产品质量和产品合格率以及以提升产品主导的全球竞争力。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Ninety percent of the students believe their universities' guidance on entrepreneurship would help their future businesses. In addition, they professed appreciation for policies intended to encourage entrepreneurship.
Baby Driver recently placed on the National Board of Review’s Top 10 list. The film holds a 93% on Rotten Tomatoes and took in over $100 million dollars at the box office.
HSBC economist Hongbin Qu said the survey pointed to lost momentum in China's manufacturing sector: He expects Beijing to respond with measures to counteract the slowdown.
Initial success was achieved in supply-side structural reform.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
200912/93010.shtml

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

While the FT online and full-time MBAs are not strictly comparable because the criteria used to judge them are slightly different, it is interesting to note that IE and Warwick Business School are among six schools to feature in both rankings.
A cemetery dating back roughly 1,700 yearshas been discovered along part of the Silk Road, a series of ancient trade routes that once connected China to the Roman Empire.
Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.
包括中国移动、阿里巴巴和腾讯的16家中国企业进入了该榜单的前100名。
但是,海外机构投资者表示,随着中国经济增长放慢,香港房地产市场已经过热,正在进入调整阶段。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields),去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称:“遗产是蕴藏着前景的历史。”他超爱这句话,说了不止一次。这句话被他翻来覆去地说,让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。
Maybe 'Melo's mini-fro is the missing key to an NBA Championship for the New York Knicks. Oh no, wait, the missing link is Jeremy Lin—but still, 'Melo's mini-fro wouldn't hurt the Knicks' title hopes.
invigorate

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

If we ask "What salary are you looking for?" say you're flexible, or say it depends on the responsibilities of the job. Try not to name a salary unless we really push you, because that gives us a leg up in the negotiating.
"We hope the mother will come to us and verify the facts. If it's true that the user is a 13-year-old who spent the money without consent, we can negotiate a refund," the Tencent employee said.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

S%(Q1(LYA(ep)n
我花钱太多了吗?过度消费会导致压力、混乱以及财政并发症。这也可能会随着时间的流逝变为一种危险的习惯。储蓄是一个非常棒的办法,万一遇到紧急情况,你极有可能为你之前的储蓄而感到欣慰。
The auction house says seven records in all were set at the Geneva auction including the highest amount ever paid for a yellow diamond - $16.3 million for the 100.09-carat Graff Vivid Yellow diamond ring.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 首部木门窗国家标准将实施
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

If you have been out of work for a long time, it may be time to consider taking a job you wouldn't have looked at before.
The drama won much praise for its use of slow motion when shooting martial arts.
200912/93010.shtml

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 特色小镇发展开始“做减法”
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

郭晶晶与霍启刚(香港近代富豪霍英东的孙子)的秘密恋情已经引起了全民的想象,人们似乎在关注运动员赛场表现之余,也愈加关心起他们的私人生活了。

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

2.人工眼睛

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

1.Rain Man
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中,以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

胡润估计,中国内地目前有594位身家十亿美元以上的富豪,在香港、台湾和澳门还有94位,而美国仅有535位。
男性使用这个密码的几率是女性的2.8倍。
An iPhone displays an image of Steve Jobs as it sits with a memorial to the Apple founder and former CEO outside an Apple Store, Wednesday, Oct. 5, 2011 in New York. Jobs passed away Wednesday at the age of 56
Of the 200 nominated companies, 101 are privately-owned, while the rest are State-owned enterprises. The total value of these 200 listed brands has risen by 36 percent year-on-year to reach $696 billion, with the top 10 accounting for 46 percent of the total value.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 国开行棚改项目审批权回收总行
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

(实际上,在过去三年的节日假期里,捷蓝航空公司绝对不是航班起飞延误最糟糕的航空公司。这项殊荣要授予Comair公司,这是达美航空公司经营地区航线的公司。不过该公司在2012年假日季节开始前停业,因此我们没有让这家公司上榜。)
只有公民,而他们的选择不仅可能、而且必然会改变。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

These are the official James Bond theme songs, ranked from worst to best, with two honorable mentions because they may or may not count, but were just that good, dang it.
“治理空气,现在办法是有的,关键是看下多大决心。”

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 北京限房价项目开闸迎“大考”
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

If you want a refrigerator with a screen, might as well just stick an iPad on it. Samsung unveiled a smart refrigerator this summer that connects to wi-fi to help manage groceries and leave notes behind for family members.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

中国的各个创新指标显现出“持续稳健的进步”,高锐表示,“没有理由认为这前进的脚步会停下来。”
previous
This habit can seriously hurt you in a work setting. If you’re one of those folks who believes that you do your best work at the last minute and put off projects or assignments until the day (or hour) before they’re due, you may not be aware of the impact your habit is having on your co-workers.If your last-minute rush requires others to work quickly, you will likely anger them, and you’ll be the first one blamed when a project fails or isn’t completed on time.
China's 2016 office box sales are expected to exceed the 2015 total of 44 billion yuan (6.8 billion U.S. dollars), the country's film watchdog said.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

Mr Hoogewerf said that Mr Wang delisted his group’s property arm from the Hong Kong stock exchange this year in the hope of realising a richer valuation for it on the Shanghai or Shenzhen bourse.
"He said if he didn't get that package within the next 53 years, he would call to complain," university spokeswoman Christine Kindl told Reuters news agency.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

《权力的游戏》不仅是秋季剧中下载次数最多的美剧,还是全年美剧下载之王。数据统计,使用非法下载方式来观看这部剧的人比用电视看的人还要多得多。
“有个家伙请了一支军乐队来陪他宣布离职。”
At the age of 12, most girls are battling with their parents to get their ears pierced, learning the ropes at senior school and preparing for life as a teenager.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 家居电商3岁 经营模式仍在探路
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

Do you tend to hide your feelings from others?
过去三年,由于北京决定在官方总收入中增加新的服务费,有关中国票房增长的结论变得复杂起来。
When researchers at the University of Illinois set out to create a device that identifies chemicals by their scent, they didn't settle for the sensitivity of the human nose. Instead, they created an artificial nose that uses the smell of bacteria to identify and diagnose specific diseases.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

n. 董事,经理,主管,指导者,导演
《秦时丽人明月心》

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Obama's projected victory would set the country's course for the next four years on spending, taxes, healthcare, the role of government and foreign policy challenges such as the rise of China and Iran's nuclear ambitions。
[flait]
几十年来,白人身份认同话语只存在于白人至上论的语境之中。当白人至上论成为禁忌,白人身份政治就陷入一种失语状态。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

The 25 most common passwords have been released by Splashdata which makes password management applications.
中国房价在今年初曾以9.6%的同比增速快速上涨,但此后随着经济放缓以及很多中等规模城市遭遇房产供应过剩,房价一直在下跌。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

80年来,普华永道(PwC)一直负责奥斯卡奖的计票工作并确保将正确的信封交给颁奖嘉宾。这家会计师事务所很快向两部影片、颁奖嘉宾和观众作出了道歉,因为它交给比蒂和唐纳薇的颁奖通告不是关于这个奖项的。
Foreign investment in emerging markets has dropped to the lowest level since the financial crisis as investors are braced for the fallout of the first US interest rate rise in nearly a decade.
6.头戴式电脑出现

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Caleb Rogers is one of two people facing legal action from gaming studio Epic Games for using cheat software to play the game Fortnite.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
From the themed collection: 壁纸市场洗牌期 催生三四级市场
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Warren Buffett reclaimed the No. 2 spot on the list for the first time since 2014, with a net worth of $75.6 billion, up from $60.8 billion in 2016.
I have never ordered an ice bucket for my red wine. In fact, come to think of it, I have never ordered an ice bucket for white wine, Champagne or dessert wine.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields),去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称:“遗产是蕴藏着前景的历史。”他超爱这句话,说了不止一次。这句话被他翻来覆去地说,让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。
我是否徘徊过去?回顾过去,沉迷于我们遗憾或者错过的事情是非常诱人和几乎令人不由自主的。学会放手,只专注于当前发生的事和你今日将要面临的选择吧。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
From the themed collection: 35城一手房存销比逼近六年低点
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

教育部在一场新闻发布会上表示,全球大多数的留学生都是来自中国。
在2013年的这次调查中,东京重新获得“全球最贵城市”的头衔。瑞士苏黎士由于汇率波动在去年名列榜首,但今年由于政府采取了控制汇率措施,在榜单上下滑至第七。日本大阪成为全球第二贵的城市。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

The renewal of the 70-year term of land-use rights by urban-dwelling owners will be no problem. No application needs to be filed, there will be no preset conditions and it will not affect any deal being made over the property.
1. Hundreds of genes spring to life after you die - and they keep functioning for up to four days. Together with an unexplained case in March that recorded brain activity in a corpse up to 10 minutes after death, we're starting to realise that death as we know it still retains some strange signs of life.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

总部位于芝加哥的竞争对手科尔尼(AT Kearney)也在为领导层变动做准备,计划于2018年第一季度投票决定接替约翰奥利格(Johan Aurik)的人选。管理合伙人最多担任两个任期,而奥利格已经期满。预计他的继任者将专注于让科尔尼做大,摆脱中等规模参与者之列。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

“有个员工的父母跟公司联系,告诉我们说,他们的儿子辞职了。”
科派斯塔克说,人们对经济紧缩和欧元稳定的忧虑使得过去一年欧元区城市的生活成本指数降低了,而加拉加斯能跻身前20则是由于人为的高汇率管制。
9月份CPI录得1.6%的同比涨幅后,经济学家曾预测10月份的同比涨幅为1.5%。中国政府为今年全年设定的通胀目标为“3%左右”。
The surviving cat, since named Trooper, has recovered and found a new home.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

10、《星球大战:侠盗一号》

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

This has given “edtech” start-ups, such as Silicon Valley-based Coursera and London-based FutureLearn, a foothold in the market. Expect them to continue this year, perhaps with a merger with a bricks-and-mortar higher education establishment.
Google's top 10 searches for 2017–U.S.
天蓝、地绿、水清的美丽中国

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 下一轮调控重点须从房价转向地价
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Sarah Collins
Yes. Mrs May lost most of her authority with the bungled snap election. But the past few months have been kinder. Sealing a Brexit divorce deal has ensured short-term job security. So until Brexit is formally complete in 2019, or an appealing alternative emerges, the Conservative party will keep her where she is. Remainers and Leavers alike wish to avoid a civil war that would be sparked by moving against her. What was thought to be an unsustainable position is proving surprisingly sustainable.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

China's Internet industry is often derided as a realm for knockoffs, especially of companies banned in China. Chinese search giant Baidu Inc. has a website that looks like Google Inc's. Tencent's flagship product, instant messaging service QQ, was launched in 1999 as OICQ and had similar functions to then-popular instant messaging service ICQ. Sina Corp.'s Weibo, a popular microblogging service, is invariably described as 'Twitter-like' in the Western media.
Cross talk (Guo Degang and Yu Qian)

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 解读智能家居的优缺点及六大挑战
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Despite Sotheby’s branding the two-part auction as “The Bernheimer Collection,” his stock proved a hard sell. Only 22 out of the 42 lots at the Nov. 24 evening sale found buyers, with a top price of 197,000 with fees for the 1732 Nicolas Lancret painting, “Le Menuet” — a frothy “fête champêtre” scene with childlike dancers — that had been purchased for $744,000 at auction in 2005.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Wish many good wishes for the holidays and the coming year.新的一年,向你献上最诚挚的祝福。
4. 学会自我推销。
我们不希望看到打贸易战,贸易战带不来贸易公平,而且双方都受损。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

凯投宏观(Capital Economics)中国经济学家朱利安?埃文斯-普里查德(Julian Evans-Pritchard)评论道:“结果是,上个月中国的贸易看起来惊人强劲。在全球需求强劲的背景下,我们预期未来数月出口还将继续表现良好。”
French business schools top the 2017 ranking. Edhec Business School, based in Lille and Nice, leads the field for the first time. HEC Paris, which dominated this ranking since its first edition in 2011, drops to second place.
Leila Janah
senior

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 石材行业洗牌 人造石降成本
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

The Caixin-Markit manufacturing purchasing managers’ index dipped to 50.8 in November, down from 51 in October and coming closer to the 50-point threshold that delineates expansion from contraction. A median forecast from economists polled by Reuters had predicted a fall to 50.9.
It was 8.9% in 2015 and 9.9% in 2014. The expenditure accounted for 2.11% of last year's total GDP, compared with 2.06% in 2015.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

在我们有别于从前的失常状态中,她用所需要的一切使人们联想到生活的失重感。“这是一个时代的终结吗?这是美国的末日吗?”她在《When the World Was at War We Kept Dancing》(《当世界陷入战争之中,我们要继续跳舞》)这首歌中吟唱着。“不,这只是开始。”
单词hospitality 联想记忆:
今年,纽约市公寓的平均售价突破了100万美元(约合人民币623万元),这是一个影响深远的里程碑。随着城市人口的激增,错过了上一轮楼市繁荣期的社区,都见证了房价和楼盘数量的增长。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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[st?:]
3.The Jungle Book

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