Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
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Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Baoneng is believed to have borrowed heavily to fund its share purchases in Vanke and is now the developer’s largest single shareholder with a 25 per cent stake.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
We should stipulate at this point that neither of us have any idea how good this draft is going to be because the college season is barely underway. It sure looks nice, what with all those freshmen stacked up together in the lottery.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
“Tangerine” (Sean Baker)
It was the second weekend in a row that Venezuela's socialist government opened the long-closed border with Colombia and by 6 a.m. Sunday a line of would-be shoppers snaked through the entire town of San Antonio del Tachira. Some had traveled in chartered buses from cities 10 hours away.
Trends and targets in antiviral phototherapy
Yan Pu, head of portfolio review in Asia at Vanguard, suspects the Asian product mix may be holding things back. For example, Asian providers offer plenty of equity ETFs but very few fixed income products. In the US, she notes, fixed income ETFs are growing rapidly.
“Even though there is significant awareness [of the role of Fed policy], market dynamics can become unstable or unfavourable relatively easily,” he says. “Then you get into a self-reinforcing cycle of selling pressure.”
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
201202/172834.shtmlChinese entrepreneur Wang Xing stays in touch with a sister in California and an uncle in Australia through chat software that offers a glimpse of how China's Internet companies can compete globally.
'I was blown away by him,' Kushner recalls. 'The first time I interacted with him was at News Corp, when he was meeting with Murdoch, and I was looped in to provide perspective. Nick described the vision of what he was trying to accomplish. And he was providing insight to Rupert.' D'Aloisio's stage presence, coupled with the deep-pocketed credibility brought by Li, attracted a large group of benefactors to Summly, including Ashton Kutcher, Yoko Ono and Stephen Fry.
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Transforming and upgrading the real economy through innovation
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
In the foreseeable future, China will see the boom of enterprises in tertiary industry. Related majors, including law, journalism and communication, and management, are expected to play a bigger role, according to the report.
Amazon founder Jeff Bezos rose to No. 3 on the list for the first time, thanks to the jump in in Amazon shares, which boosted his net worth to $72.8 billion.
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
节目37 相声《东西南北大拜年》，赵炎 逗笑 逗乐 大新等
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
这些各不相同的胡子是设计师弗朗西丝·汉农(Frances Hannon)设计的，在安德森的多部电影中（比如《青春年少》[Rushmore]和《水中生活》[The Life Aquatic With Steve Zissou]），她都为比尔·默里(Bill Murray)设计了面部毛发。这次，她让该片的很多演员留起胡子，供她修剪成任何想要的形状。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
尽管中国在设计制造能与波音737或空客A320媲美的大飞机上仍有很长的路要走，但发展趋势很显著。中国航空工业正走向一个崭新的发展阶段并不断迈向成熟。The first flight of the Comac C919. Credit: Comac
Influenza neuraminidase: A druggable target for natural products
3. You support the teams that I support.
The data measure how successful alumni have been in their career in terms of salary, seniority and achievements since graduating.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
However, in season two Friends took a big leap toward equality by featuring a gay wedding when Carol married her girlfriend Susan. Behind the scenes, executive producer Marta Kauffman said, "NBC expected thousands and thousands of phone calls and hate mail." However, after the episode aired, they received only four antagonistic letters. As it turns out, people just didn't care that much.
《副总统》(Veep)：Netflix公司的热门剧《纸牌屋》(House of Cards)今年露出疲态，但另一部讽刺华盛顿的HBO电视剧《副总统》却在第三季中更上一层楼。塞琳娜（朱莉娅·路易斯-德莱弗斯[Julia Louis-Dreyfus]饰）和助手加里（Gary，托尼·黑尔[Tony Hale]饰）在洗手间里发现自己即将成为总统后，激动得失声大笑，成为2014年喜剧片中最滑稽的一幕。
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
"The online Internet anti-corruption bid mostly relies on text, photos and videos and it is easy to be superficial if corrupt officials are only exposed this way."
We will step up the development of public facilities in rural areas.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Ninety percent of the students believe their universities' guidance on entrepreneurship would help their future businesses. In addition, they professed appreciation for policies intended to encourage entrepreneurship.
Baby Driver recently placed on the National Board of Review’s Top 10 list. The film holds a 93% on Rotten Tomatoes and took in over $100 million dollars at the box office.
HSBC economist Hongbin Qu said the survey pointed to lost momentum in China's manufacturing sector: He expects Beijing to respond with measures to counteract the slowdown.
Initial success was achieved in supply-side structural reform.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
His eloquent defence of equality came after a year of faltering progress on gay marriage in the US and as arguments rage about the lack of diversity among the people running the Silicon Valley companies, including Apple, who shape so much of our culture.
Inhibition of SARS coronavirus helicase by bismuth complexes
While the FT online and full-time MBAs are not strictly comparable because the criteria used to judge them are slightly different, it is interesting to note that IE and Warwick Business School are among six schools to feature in both rankings.
A cemetery dating back roughly 1,700 yearshas been discovered along part of the Silk Road, a series of ancient trade routes that once connected China to the Roman Empire.
Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields)，去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称：“遗产是蕴藏着前景的历史。”他超爱这句话，说了不止一次。这句话被他翻来覆去地说，让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。
Maybe 'Melo's mini-fro is the missing key to an NBA Championship for the New York Knicks. Oh no, wait, the missing link is Jeremy Lin—but still, 'Melo's mini-fro wouldn't hurt the Knicks' title hopes.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
If we ask "What salary are you looking for?" say you're flexible, or say it depends on the responsibilities of the job. Try not to name a salary unless we really push you, because that gives us a leg up in the negotiating.
"We hope the mother will come to us and verify the facts. If it's true that the user is a 13-year-old who spent the money without consent, we can negotiate a refund," the Tencent employee said.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The auction house says seven records in all were set at the Geneva auction including the highest amount ever paid for a yellow diamond - $16.3 million for the 100.09-carat Graff Vivid Yellow diamond ring.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
If you have been out of work for a long time, it may be time to consider taking a job you wouldn't have looked at before.
The drama won much praise for its use of slow motion when shooting martial arts.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
在根据真实罪案改编的电影《狐狸猎手》(Foxcatcher)中，以出演喜剧闻名的演员史蒂夫·卡瑞尔(Steve Carell)饰演大富翁约翰·E·杜邦(John E. du Pont)时隐藏在假面具后面。这个造型最突出的就是鸟嘴状鼻子。
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
An iPhone displays an image of Steve Jobs as it sits with a memorial to the Apple founder and former CEO outside an Apple Store, Wednesday, Oct. 5, 2011 in New York. Jobs passed away Wednesday at the age of 56
Of the 200 nominated companies, 101 are privately-owned, while the rest are State-owned enterprises. The total value of these 200 listed brands has risen by 36 percent year-on-year to reach $696 billion, with the top 10 accounting for 46 percent of the total value.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
These are the official James Bond theme songs, ranked from worst to best, with two honorable mentions because they may or may not count, but were just that good, dang it.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
If you want a refrigerator with a screen, might as well just stick an iPad on it. Samsung unveiled a smart refrigerator this summer that connects to wi-fi to help manage groceries and leave notes behind for family members.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
This habit can seriously hurt you in a work setting. If you’re one of those folks who believes that you do your best work at the last minute and put off projects or assignments until the day (or hour) before they’re due, you may not be aware of the impact your habit is having on your co-workers.If your last-minute rush requires others to work quickly, you will likely anger them, and you’ll be the first one blamed when a project fails or isn’t completed on time.
China's 2016 office box sales are expected to exceed the 2015 total of 44 billion yuan (6.8 billion U.S. dollars), the country's film watchdog said.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Mr Hoogewerf said that Mr Wang delisted his group’s property arm from the Hong Kong stock exchange this year in the hope of realising a richer valuation for it on the Shanghai or Shenzhen bourse.
"He said if he didn't get that package within the next 53 years, he would call to complain," university spokeswoman Christine Kindl told Reuters news agency.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
At the age of 12, most girls are battling with their parents to get their ears pierced, learning the ropes at senior school and preparing for life as a teenager.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Do you tend to hide your feelings from others?
When researchers at the University of Illinois set out to create a device that identifies chemicals by their scent, they didn't settle for the sensitivity of the human nose. Instead, they created an artificial nose that uses the smell of bacteria to identify and diagnose specific diseases.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Obama's projected victory would set the country's course for the next four years on spending, taxes, healthcare, the role of government and foreign policy challenges such as the rise of China and Iran's nuclear ambitions。
A modular microarray imaging system for highly specific COVID-19 antibody testing
The 25 most common passwords have been released by Splashdata which makes password management applications.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Foreign investment in emerging markets has dropped to the lowest level since the financial crisis as investors are braced for the fallout of the first US interest rate rise in nearly a decade.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Caleb Rogers is one of two people facing legal action from gaming studio Epic Games for using cheat software to play the game Fortnite.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Warren Buffett reclaimed the No. 2 spot on the list for the first time since 2014, with a net worth of $75.6 billion, up from $60.8 billion in 2016.
I have never ordered an ice bucket for my red wine. In fact, come to think of it, I have never ordered an ice bucket for white wine, Champagne or dessert wine.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
而最终取得压倒性胜利的是福特公司(Ford)的CEO马克?菲尔茨(Mark Fields)，去年年初他曾令人沮丧地宣布他的公司正“从一家汽车公司向一家汽车公司兼出行公司转型”。他紧接着声称：“遗产是蕴藏着前景的历史。”他超爱这句话，说了不止一次。这句话被他翻来覆去地说，让我觉得它不像格言反倒更像废话。因此本年度新晋“首席蒙人冠军”(Chief Obfuscation Champion)非菲尔茨先生莫属。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The renewal of the 70-year term of land-use rights by urban-dwelling owners will be no problem. No application needs to be filed, there will be no preset conditions and it will not affect any deal being made over the property.
1. Hundreds of genes spring to life after you die - and they keep functioning for up to four days. Together with an unexplained case in March that recorded brain activity in a corpse up to 10 minutes after death, we're starting to realise that death as we know it still retains some strange signs of life.
A facile assay for rapid detection of COVID-19 antibodies
总部位于芝加哥的竞争对手科尔尼(AT Kearney)也在为领导层变动做准备，计划于2018年第一季度投票决定接替约翰奥利格(Johan Aurik)的人选。管理合伙人最多担任两个任期，而奥利格已经期满。预计他的继任者将专注于让科尔尼做大，摆脱中等规模参与者之列。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The surviving cat, since named Trooper, has recovered and found a new home.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
This has given “edtech” start-ups, such as Silicon Valley-based Coursera and London-based FutureLearn, a foothold in the market. Expect them to continue this year, perhaps with a merger with a bricks-and-mortar higher education establishment.
Google's top 10 searches for 2017–U.S.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Yes. Mrs May lost most of her authority with the bungled snap election. But the past few months have been kinder. Sealing a Brexit divorce deal has ensured short-term job security. So until Brexit is formally complete in 2019, or an appealing alternative emerges, the Conservative party will keep her where she is. Remainers and Leavers alike wish to avoid a civil war that would be sparked by moving against her. What was thought to be an unsustainable position is proving surprisingly sustainable.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
China's Internet industry is often derided as a realm for knockoffs, especially of companies banned in China. Chinese search giant Baidu Inc. has a website that looks like Google Inc's. Tencent's flagship product, instant messaging service QQ, was launched in 1999 as OICQ and had similar functions to then-popular instant messaging service ICQ. Sina Corp.'s Weibo, a popular microblogging service, is invariably described as 'Twitter-like' in the Western media.
Cross talk (Guo Degang and Yu Qian)
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Despite Sotheby’s branding the two-part auction as “The Bernheimer Collection,” his stock proved a hard sell. Only 22 out of the 42 lots at the Nov. 24 evening sale found buyers, with a top price of 197,000 with fees for the 1732 Nicolas Lancret painting, “Le Menuet” — a frothy “fête champêtre” scene with childlike dancers — that had been purchased for $744,000 at auction in 2005.
Anti-HIV drug repurposing against SARS-CoV-2
Wish many good wishes for the holidays and the coming year.新的一年，向你献上最诚挚的祝福。
Length-scale dependence of protein hydration-shell density
凯投宏观(Capital Economics)中国经济学家朱利安?埃文斯-普里查德(Julian Evans-Pritchard)评论道：“结果是，上个月中国的贸易看起来惊人强劲。在全球需求强劲的背景下，我们预期未来数月出口还将继续表现良好。”
French business schools top the 2017 ranking. Edhec Business School, based in Lille and Nice, leads the field for the first time. HEC Paris, which dominated this ranking since its first edition in 2011, drops to second place.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The Caixin-Markit manufacturing purchasing managers’ index dipped to 50.8 in November, down from 51 in October and coming closer to the 50-point threshold that delineates expansion from contraction. A median forecast from economists polled by Reuters had predicted a fall to 50.9.
It was 8.9% in 2015 and 9.9% in 2014. The expenditure accounted for 2.11% of last year's total GDP, compared with 2.06% in 2015.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
在我们有别于从前的失常状态中，她用所需要的一切使人们联想到生活的失重感。“这是一个时代的终结吗？这是美国的末日吗？”她在《When the World Was at War We Kept Dancing》（《当世界陷入战争之中，我们要继续跳舞》）这首歌中吟唱着。“不，这只是开始。”
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3.The Jungle Book